University of Sydney: $40m funding boost for Sydney medical research
Projects to embed RNA diagnostics within the Australian health system, improve timely dementia diagnoses, and evaluate immunotherapy treatments for a rare yet expensive to treat neurological disorder are among the latest projects funded.
This year University of Sydney researchers have been awarded almost $40 million under the Australian Government’s Medical Research Future Fund, with projects spanning cardiovascular disease, dementia, genomics and more.
The Medical Research Future Fund aims to transform health and medical research and innovation, improve lives, build the economy and contribute to health system sustainability.
Executive Dean and Pro Vice-Chancellor Medicine and Health Professor Robyn Ward congratulated the grant recipients.
“I’d like to congratulate all of our successful grant recipients.”
“This is an outstanding result for the University which demonstrates the breadth of our world-class research across priority areas in public health – cardiovascular disease and dementia – and in emerging areas of research, such as genomics. These projects will have a lasting impact on the Australian health system and the health outcomes of many people.”
Some highlights from the latest grant announcements have been expanded on below. A full list of the successful MRFF projects and research teams is available at the end of the article.
Professor Sandra Cooper from Kids Neuroscience Centre at Children’s Hospital at Westmead, Faculty of Medicine and Health and the Children’s Medical Research Institute, and her team were awarded more than $2.9 million to embed RNA diagnostics within the Australian health system and provide genetic answers for families who previously had none.
A genetic diagnosis is a crucial turning point for families affected by rare disorders or an inherited predisposition to cancer. It helps enable early diagnosis, early intervention, reproductive counselling, disease prevention and potential eligibility for relevant clinical trials.
Professor Ainsley Newson
Professor Ainsley Newson from Sydney Health Ethics in the Faculty of Medicine and Health was awarded almost $5 million for a project looking at the ethical governance for clinical and genomic data.
LINEAGE will bring together leading researchers, patients and First Nations peoples to address pressing ethical, legal and social issues in the development and use of genomic datasets. The project will develop, implement, and evaluate solutions to deliver a national governance framework for these data, facilitating the successful integration of genomic information in Australian health care.
Professor Lee-Fay Low
Professor Lee-Fay Low from the Faculty of Medicine and Health and her team were awarded more than $1.9 million to work towards improving timely dementia diagnosis and post-diagnostic treatment and support.
The team will compare a public health campaign and a primary care practice change program implemented individually or jointly. They will work with three primary healthcare networks Wentwest (Western Sydney), Western Victoria and Adelaide. The project aims to increase knowledge about dementia, decrease stigma, and increase motivations and triggers around obtaining or providing diagnosis and early treatment.
Professor David Brown from the Faculty of Medicine and Health and the Westmead Institute for Medical Research and his team were awarded more than $2.8 million to evaluate immunotherapy treatments for chronic inflammatory demyelinating polyneuropathy (CIDP), an uncommon but expensive to treat neurological disorder.
Targeting and eliminating immune cells has significantly improved outcomes for patients with neurological and inflammatory demyelinating diseases.
This study will determine if removing B-lymphocytes, a type of white blood cell which makes antibodies, might be a suitable early treatment for CIDP and lead to responses that will allow less immunoglobin (which is costly) to be used to manage the condition.
Dr Louise Thornton
Dr Louise Thornton from the Matilda Centre for Research in Mental Health and Substance Use received $993,682 for an e-health project that aims to prevent cardiovascular disease among adolescents.
E-Health or digital approaches, such as websites and mobile apps, have significant potential to help adolescents make behaviour changes that will reduce their risk of developing health issues like cardiovascular disease later in life.
The research aims to address a critical knowledge gap by increasing the understanding of how digital approaches can better engage adolescents with their health. This knowledge will be used to help engage adolescents across Australia with a free app for cardiovascular disease prevention called ‘Health4Life.’
Associate Professor Natasha Rogers from the Westmead Institute for Medical Research and Faculty of Medicine and Health received $865,397 for a project that will explore the role of uremic toxins (substances that accumulate in the body liquids of people with kidney disease) and matrix proteins (proteins that form on the inside of a viral envelope) in chronic kidney disease and its link to developing cardiovascular disease.
The study will also use cutting-edge echocardiography and cardiac magnetic resonance imaging technology to explore the potential of non-invasive imaging and matrix proteins as markers of heart disease of unknown origin in patients with renal impairment.
Professor Roland Stocker from the Faculty of Medicine and Health and Heart Research Institute received $999,000 for a project assessing the potential of non-invasive imaging of the activity of myeloperoxidase, an enzyme in the immune system, which is released to provide defence against invading pathogensas, and acts as a biomarker for vascular inflammation and the detection of high-risk atherosclerosis.
Associate Professor Fiona Stanaway
Associate Professor Fiona Stanaway from the Sydney School of Public Health, Faculty of Medicine and Health received $782,008 for a project quantifying ethnic inequalities in access to best care for cardiovascular disease.
International research has demonstrated large inequalities related to ethnicity in the frequency of cardiovascular disease, its outcomes and access to care. However, many of these inequalities remain unrecognised in Australia and fail to be targeted because of limitations in the way that ethnic diversity is measured in the health system and analysed in research.
The project will access multiple measures of cultural and linguistic diversity and visa class information from the Australian Census and Migration datasets, and link these to Commonwealth and state (New South Wales) held health data. This will allow identification of ethnic groups with reduced access to best care for cardiovascular disease and identify what is behind reduced access.
Professor Robyn Gallagher
Professor Robyn Gallagher from the Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health and the Charles Perkins Centre received $894,507 for a project on best-practice cardiac rehabilitation.
Effective strategies to reduce mortality and hospitalisations from coronary heart disease are widely available through high quality cardiac rehabilitation programs, however, many Australians are not benefiting from these due to access inequality and varying availability.
This project will evaluate the effectiveness of the Quality Improvement in Cardiac Rehabilitation (QUICR) program by measuring program uptake and completion (primary), unplanned hospitalisations, exercise capacity, quality of life and proportions receiving guideline-based care such as wait-time, entry or completion assessment, and discharge transition plans.
It will also identify key barriers and enablers to implementation of the program and cost-effectiveness.
Dr Freda Passam from the Charles Perkins Centre, Central Clinical School in the Faculty of Medicine and Health, and Royal Prince Alfred Hospital received $659,293 for work on new platelet targets to improve the management of coronary artery disease.
Patients often receive anti-platelet drugs to prevent future cardiac events after an initial coronary event (such as a heart attack or angina), however, anti-platelet drugs prevent less than a quarter of future lethal cardiovascular events.
This project aims to develop a platform to identify platelet targets to monitor and treat residual risk of blood clots despite anti platelet treatment and to discover alternative pathways to aid recovery from coronary heart disease.
Associate Professor Sarah Norris from the Charles Perkins Centre, Menzies Centre for Health Policy and Economics and the Faculty of Medicine and Health, received $2.1 million.
Genomic screening of newborns has the potential to identify hundreds of genetic conditions. But before the widespread genomic screening of newborns is adopted in Australia, it is important to understand the perspectives of all community members regarding the ethics and equity of using DNA sequencing for this purpose. This project will research the views of the general population, people living with genetic conditions, patient advocates, clinicians, health service providers, and policy makers to co-develop health technology assessment tools for policy makers that integrate the 4 Es of ethics, equity, effectiveness and economics.
Associate Professor Bruce Bennetts from The Children’s Hospital at Westmead and the Faculty of Medicine and Health received $2.9 million.
Newborn genomic screening for inherited conditions continues to be one of the most successful population health programs, providing benefits to a target population through diagnosing serious health conditions early. This study will accelerate capabilities for using whole genome sequencing technologies in national newborn screening programs by assessing their feasibility, scalability (automation and bioinformatics), effectiveness and acceptability, alongside increasing logistical capacity and resources.
Dr Anai Gonzalez Cordero from the Faculty of Medicine and Health and Children’s Medical Research Institute, received $2.5 million for the development of photoreceptor cell therapy to treat blindness. There is an unmet need for treatment for millions of people worldwide living with severe eye diseases.
Cell therapy by transplantation of photoreceptors offers a tangible treatment option. This project proposes to move cell therapy closer to implementation by establishing a process development pipeline to generate an allogeneic stem cell-derived photoreceptor product compatible with good manufacturing practices.
The team will collaborate with the Murdoch Children’s Research Institute and Cord Blood Bank to produce Australia’s first good manufacturing practice compatible bank of induced pluripotent stem cells iPSC lines – a starting material to model human disease in relevant cell types. These cell lines will then be used to generate the photoreceptor cells.
They will also work in collaboration with the Behavioural Sciences Unit at UNSW to evaluate the perception of patients and the public regarding stem cell therapies and clinical trials.
Honorary Senior Principal Research Fellow at the Charles Perkins Centre, Professor Alex Brown, was announced as overall lead of a Genomics Health Futures Fund grant.
Professor Brown will lead a project to establish a national First Nations Indigenous Genomics Network. Professors Stephen Simpson, David James and Jean Yang from the Charles Perkins Centre, will work with colleagues from UNSW, Garvan and Victor Chang institutes to lead the NSW node of the project in Precision Medicine.