New Research Reveals Preventable Risk Factors Contribute to Significant Number of Parkinson’s Disease Cases

The 1,223 persons studied at UAB hailing from the Southern region of the United States included 808 with PD and 415 neurologically healthy controls. Researchers came away with two significant findings that indicated that preventable risks affect the risk of Parkinson’s disease: repeated blows to the head and exposure to herbicides and pesticides.

First, the study found that repeated blows to the head in sports or military combat that seem harmless and may not even cause concussion doubled a person’s risk of developing PD later in life. Second, 23 percent of cases of PD in both men and women were associated with exposure to pesticides, herbicides or military-related chemical exposures. Together, head injury and exposure to environmental toxins may account for nearly one in three cases of PD in men, and one in four in women.

“Parkinson’s disease is rising fast globally, and there is an unspoken assumption that there is no prevention — but there is,” said Haydeh Payami, Ph.D., professor and John T. & Juanelle D. Strain Endowed Chair in the UAB Department of Neurology, faculty in the Center for Neurodegeneration and Experimental Therapeutics, and the study’s lead author. “Our research demonstrated that a substantial fraction of PD in the Deep South is attributable to risk factors that can be reduced or avoided. Our paper puts a number on how many cases of PD could potentially be prevented if toxic chemicals were eliminated and if we made contact sports like football safer.”

While genes play an important part in a person’s exposure to PD cases, with about 5 percent of cases caused by genetic mutations that are hereditary, the other 95 percent of PD cases are thought to be caused by various external factors that cause disease in individuals who are genetically susceptible to their damaging effect.

As the research for this study was conducted at UAB and research participants were all from the Deep South, Payami shared that findings indicate that incidence of disease will likely vary by population depending on how prevalent the risk factors are. For instance, in Europe, where many of the toxic chemicals that are commonly found in American products are banned, a lower fraction of Parkinson’s disease could be attributed to those specific chemicals. Furthermore, numbers could change with time for better or worse, depending on actions taken now to clean the environment and improve health and safety standards.

The study was funded by grants from the U.S. Army Medical Research Materiel Command endorsed by the U.S. Army through the Parkinson’s Research Program Investigator-Initiated Research Award under Award No. W81XWH1810508 and Aligning Science Across Parkinson’s [ASAP-020527] through the Michael J. Fox Foundation for Parkinson’s Research.