University of Cape Town- COVID-19: insights and lessons with Prof Marc Mendelson

Prof Marc Mendelson said that without rapid COVID-19 vaccinations, population immunity won’t be possible and a third wave is on the cards.
“Without rapid vaccination of at least two thirds of the population, we (South Africa) are not going to get to population immunity, and without that, we will see another wave.”

This was according to Professor Marc Mendelson, who presented a virtual Summer School lecture titled “COVID-19 insights and lessons” on Saturday, 16 January 2021.

Professor Mendelson is the head of the Division of Infectious Diseases and HIV Medicine at Groote Schuur Hospital, the immediate past president of the International Society for Infectious Diseases and the past president of the Federation of Infectious Diseases Societies of Southern Africa.

South Africa is currently gripped by a second wave of COVID-19 infections, and scientists have identified a new variant – 501.V2 – which is driving the infection surge in the country.

“[Globally], this pandemic has been the greatest challenge to the public health system that we’ve ever seen, and it’s associated with a scientific endeavour that we have never seen before,” Mendelson said.



“As a country we still face deep problems with severe issues around vaccine strategy, and we haven’t even talked about vaccine denial.”

“We’re definitely better off a year down the line, but there are a huge number of things that we need to answer. As a country we still face deep problems with severe issues around vaccine strategy, and we haven’t even talked about vaccine denial.”

COVID-19 transmission

Mendelson explained that the virus sits in the upper respiratory tract (nose and nasal passages), as well as in the lungs, and can be transmitted through large droplets expelled from the upper airways.

If infected people expel large droplets containing the virus, these relatively heavy droplets fall to the ground quite quickly. Smaller droplets, on the other hand, remain airborne. Clinically and epidemiologically, evidence suggests that COVID-19 is transmitted by large droplets, he said.



“Because droplets drop onto surfaces … you will need to clean surfaces and wash your hands well. This is the science behind the use of masks, handwashing, social distancing and ventilation.”

“The household infection rates were high. A very large number of cases, the vast majority [in fact], were within families in close proximity [to one another]. This, epidemiologically, suggests that large droplets play a role in transmission.

“If you want to reduce transmission from large droplets, then you need to increase the distance you are from someone. Also, because droplets drop onto surfaces … you will need to clean surfaces and wash your hands well. This is the science behind the use of masks, handwashing, social distancing and ventilation.”

However, in some studies, particularly those that involve hospitalised patients, Mendelson said that the virus has also been found in remote areas of hospital rooms, not just near the patient’s bedside. Droplets have been found on air fans, ceilings and walls – and at a distance from the patient. Therefore, he explained, it appears that COVID-19 can also be transmitted by aerosols (smaller droplets).

“If you want to reduce aerosols, one way of doing that is to improve ventilation. The more the air is changed, the [quicker] it will dilute small droplets,” he said.

The new variant

Mendelson said that scientists detected a new strain of COVID-19 in parts of the country in September 2020. Now, Mendelson said, “pretty much all infections” in the country are dominated by the new variant.

He said that the new strain contains a large number of mutations, and the viruses that scientists continue to genotype have emerged with the same mutations. These mutations, he explained, sit in the area of the spike protein of SARS-CoV-2, which “antibodies generally recognise”.



“Scientific evidence is rapidly being worked on by a research consortium across South Africa.”

“Antibodies and T-cell immunity recognise the same areas, and these recognition sites are critical in our fight against the virus. If the genetic material protein changes and the spike protein changes in this variant, there is a possibility that our immune system won’t work as well.”

Mendelson said that scientists have many unanswered questions about the new strain, including whether current vaccines will offer protection against the new variant, and whether people previously infected with a different strain will have immunity against the new variant.

“Scientific evidence is rapidly being worked on by a research consortium across South Africa … to find out exactly what’s happening and what the answers will be.”

Government’s vaccine roll-out plan

Government’s vaccine roll-out plan will be divided into three categories: phase one will focus on frontline healthcare workers; phase two will focus on essential workers, the elderly and persons with comorbidities; and phase three will focus on other people 18 years and older.

“Our response has been slow, even though it is now accelerating.”

“The bottom line is that our response has been slow, even though it is now accelerating,” Mendelson said.

“We’ve been promised by the president that 67% of the population is going to be vaccinated by the end of the year. Remember, kids under 16 don’t get vaccinated, so we are talking about 40 million people who need to be vaccinated.”

While Mendelson said he’s not able to describe exactly what it will look like and what its effects will be, without rapid vaccination to achieve population immunity, a third wave is definitely on the cards.